Navneet Kumar Gupta
Dr. Javed N Agrewala, Professor, Centre for Biomedical Research, IIT, Ropar has been awarded the prestigious ‘JC Bose Fellowship’ for his work on the development of novel vaccination strategies against tuberculosis.
Dr Javed Agrewala with the help of his collaborator Prof David Jackson, University of Melbourne, Australia has engineered a chimeric vaccine by linking proteins of Mycobacterium tuberculosis with a unique lipid to target the vaccine to dendritic cells of the body.
Dendritic cells play a cardinal and sentinel role in initiating the immunity against any infection. This vaccine optimally activates the immunity and has been shown to protect against the disease better than the traditional BCG vaccine in the experimental model of tuberculosis.
It is totally synthetic and therefore can be used to vaccinate AIDS patients and immunocompromised individuals. In such people, BCG cannot be used because it can itself spread infection.
Developed the chimeric vaccine
Dr. Agrewala developed this vaccine by carefully studying the snags associated with BCG failure to protect public living in TB-endemic regions. He believes that this vaccine may have potential in future to successfully protect against TB.
Earlier, Dr Agrewala worked as a Chief Scientist at the CSIR-Institute of Microbial Technology, Chandigarh. In connection with this work, he has been granted United States patent and published several manuscripts in high impact journals like Trends in Molecular Medicine, Journal of Infectious Diseases, Journal of Proteome Research, Frontiers in Immunology, Critical Reviews of Microbiology, etc. Currently, he is searching an industrial partner, who can synthesize the vaccine under GLP condition for clinical trials.
About IIT Ropar
Indian Institute of Technology Ropar is one among the eight new IITs set up by the Ministry of Human Resource and Development (MHRD), Government of India in 2008. It was mentored by IIT Delhi in its formative years. IIT Ropar has been excelling in teaching as well as research since its inception.
The mission of IIT Ropar is “to foster a transformative learning environment and a culture of excellence enabling creation of knowledge and development of socially responsible, enterprising leaders contributing significantly to national progress and humanity”.
Over the last few years IIT Ropar has blossomed as one of the top technology institutions created in this millennium once securing a position among the top 10 in national institutional ranking framework (NIRF) that ranks all the technology universities within India by MHRD.
IIT Ropar has been setting up international collaborations with leading academic institutions. It aims to distinguish itself from its peers by focusing on research with high quality and practice impact. It also has a distinctive curriculum that combines rigour and relevance thereby providing a hands-on learning experience to the students.